اثر هشت هفته تمرین هوازی همراه با مصرف عصارۀ هیدروالکلی دارچین بر سطوح ویسفاتین و واسپین سرمی در موش‌های صحرایی مقاوم به انسولین

Introduction: Visfatin and Vaspin are two adipokines playing a role in increasing or decreasing insulin resistance. The present study aimed at investigating the effect of 8 weeks of aerobic exercise in combination with cinnamon extract on visfatin and vaspin in insulin-resistant rats. Methods: Thirty-six Wistar male rats were divided into four groups: control (N=9), aerobic exercise (N=9), cinnamon extract (N=9), and aerobic exercise + cinnamon extract (N=9). Insulin resistance status was induced by %10 fructose solutions during 5 weeks. The exercise groups were subjected to a 5-day per week aerobic exercise program (with 75-80% VO2max) for 8 weeks. 200 mL/kgBw/day cinnamon extract was injected to the rats in the cinnamon extract groups. The Data were analyzed using one-way ANOVA and the significance level was set at p<0.05. Results: The results showed that aerobic exercise with and without cinnamon extract significantly decreased the serum visfatin, insulin and insulin resistance (P<0.000, P<0.005 and P<0.001, respectively). Also, the Aerobic exercise and aerobic exercise + cinnamon groups significantly increased vaspin concentration (P<0.001). Glucose levels were significantly decreased in the aerobic exercise + cinnamon group (P<0.008). Conclusion: The results of the present study indicated that aerobic exercise may improve insulin resistance in insulin-resistant rats changing the levels of serum visfatin and vaspin. However, it can have a greater effect on visfatin when combined with cinnamon extract.